Ketamine is a drug mainly used for inducing and maintaining anesthetic sleep in patients undergoing surgery. It causes a profound trance-like state, giving pain relief, amnesia, and mild sedation. The drug has been used as an anesthetic agent since the early 1960s and is also used in surgical situations as a precursor to more potent anesthetics like propofolium and peroxycycline. Because of these various uses, Ketamine has been in use for decades, but its effects have been less appreciated than that of other agents of similar classifications.
Amino Acids or AMN, as it is commonly known, act on the neurons to reduce synaptic activity and neurotransmitter levels resulting in lessened symptoms of depression. The levels of neurotransmitters in the brain are believed to be important in the treatment and management of mood disorders such as depression. The levels of these chemicals are reduced as the patient undergoes ketamine therapy. Although the mechanism is not well understood, the reduction of neurotransmitter activity could result in the improvement of symptoms of the disorder.You can get additional information at California Center for Ketamine Therapy
Patients with mental health conditions, however, should be treated with care and caution and ketamine therapy should not be resorted to by people suffering from addiction. According to some research, however, this drug may be helpful in the treatment and management of anxiety, schizophrenia, schizoaffective disorder, posttraumatic stress disorder, psychosis, mania, depression, dysthymia, and mixed episodes of these three mental health conditions. However, in case of serious psychological problems like overdose, death, or severe complications, professional help should be sought. This is especially true for people using heroin, tranquilizers, antidepressants, or drugs containing amphetamines such as speed, methamphetamines, and ecstasy. Ketamine should only be administered under medical supervision due to its serious side effects.
Bipolar Disorders There are certain cases where ketamine therapy has been found very useful in the treatment of certain types of mental health conditions, particularly when the patient has a history of suicide attempts and other forms of psychiatric disorders. However, ketamine therapy should not be used in patients with bipolar disorders, especially those having a severe manic episode. In these cases, the patient must undergo an extended period of hospitalization and the use of other medications. Ketamine, although a relatively new drug, has not been approved by the FDA for these purposes. If used under the proper supervision of a psychiatrist, it can be highly effective in the treatment and management of bipolar disorders.
Clinical trials have also indicated that ketamine therapy is effective in the treatment and management of anxiety and depression. In the context of depression, patients who experience significant physical discomfort or pain during the course of their treatments are candidates for this treatment modality. The level of ketone production in these patients tends to be very high and they respond very well to this drug. Because ketamine can increase the sensitivity of certain nerve cells, patients must be carefully monitored while on this medication.
Bipolar And Cognitive Disorder: Ketamine therapy is also effective in the treatment of patients diagnosed with certain types of anxiety and depression. In this case, the term ‘completer’ is applied to the patients who exhibit symptoms of anxiety and/or depression and do not respond to other forms of treatment. These include patients diagnosed with the mood stabilizing disorder (the most common kind of BDD) as well as those who have experienced a recent catastrophic event. In the context of anxiety, this treatment modality is particularly useful in the treatment of panic disorder patients, who show an increased risk of substance abuse when left untreated. In cognitively-disabling patients, such as dementia and Parkinson’s disease, the use of ketamine therapy has been found to be quite successful.
The mechanism of action of ketamine therapy in the context of treating depression symptoms is by increasing the levels of two neurotransmitters, glutamate and GABA. When GABA and glutamate are abnormally reduced in the brain, the transmission of messages between neurons is compromised, especially in areas critical to our mood and emotional state. Ketamine, together with traditional antidepressants, acts to rectify this imbalance by interrupting the formation of new synaptic connections. While it has been found that ketamine therapy is efficacious in the treatment of patients with depression who suffer from the more severe symptom of cognitive impairment, this remains to be proven. Studies are currently underway to determine whether this intervention can be employed in the long-term treatment of patients with mild Alzheimer’s disease, another form of depression that manifests cognitive deficiencies.
Ketamine therapy is also used in the treatment of Parkinson’s disease and is known to relieve parkinsonism-like symptoms in patients with the disease. In IV-administered doses, however, the lack of a systemic pump makes this form of therapy quite inconvenient. Due to this difficulty, ketamine is usually injected intramuscularly. Intravenous injections are usually effective in lessening the side effects produced by the drug, but it is important to note that intramuscular administration of the drug may lead to allergic reactions. Long-term treatments of this nature are therefore only administered on a short term basis.